A REVIEW OF LIPROXSTATIN-1

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TAK-243 preferentially certain to UBA1 more than the similar E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lessened levels of ubiquitylated proteins, increased markers of proteotoxic tension and DNA harm stress. In vivo, TAK-243 reduced leukemic stress and targeted leukemic stem cells without evidence of toxic